What does Isaiah 7:8 mean?

The capital of Aram is Damascus, and Damascus is led by Rezin. The capital of Ephraim is Samaria, and Samaria is led by Remaliah’s son. In sixty-five years, Ephraim will be shattered and no longer a people. Isaiah 7:8 - Modern Text Bible

(God points out the limits of these nations and predicts that Israel (Ephraim) will soon be destroyed.)